Current Issue : July-September Volume : 2011 Issue Number : 3 Articles : 3 Articles
Diabetes mellitus (DM) affects over 150 million people worldwide, with a prevalence that varies markedly from population to population. Estimates predict that almost 300 million people will suffer from DM by 2025 with the vast majority being cases of diabetes mellitus type 2. Diabetes is of two types, type 1 accounting for 5% prevalence and type 2 for 95% prevalence among diabetics. The purpose of this review is to provide the reader with knowledge concerning the diabetes treatment using alternative forms of insulin delivery....
The aim of the present study was to prepare and characterize compression coated meloxicam tablets using guar gum/hydroxypropylmethylcellulose for effective delivery of drug to the colon. In vitro drug release studies were performed in the dissolution media with and without rat caecal contents. Results showed an enhanced release in rat caecal content when compared to formulation studied in dissolution media without rat caecal content, because of microbial degradation of polymer. The rate of drug release is dependent upon the coat thickness and amount of guar gum/hydroxypropylmethylcellulose used in the formulations. Combination of guar gum and hydroxypropylmethylcellulose K4M provided better protection of the drug, showing increased release lag time and controlled release rate. The nature of the drug transport was found to be non-Fickian (super case-II). Release of drug from tablets began after a time delay as a result of hydrogel swelling/retarding effect, followed by zero-order release for most of the formulations studied. The in vitro drug release studies and in vivo X-ray studies indicated that optimized formulation was a promising system to provide targeting of meloxicam to the colon....
Diabetes patients cannot produce insulin properly which is required to convert sugar, starches, and other food source into energy. Scientists have been looking for simple and effective ways to deliver insulin into the blood stream. The most common one is taking insulin pill orally. However research shows that insulin is easily broken down by the digestive system. This problem is solved by using chewing gum insulin. Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5'-hydroxyl group of the ribose moiety of a-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptide includes insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time....
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